Substituted glycine derivatives for use as medicaments

Details Substituted glycine derivatives for use as medicaments Substituted glycine derivatives for use as medicaments

C - Chemistry, Metallurgy

07

C

C07C 323/25 (2006.01) A61K 31/198 (2006.01) A61K 31/223 (2006.01) A61K 31/47 (2006.01) C07C 229/12 (2006.01) C07C 229/14 (2006.01) C07C 323/32 (2006.01) C07D 217/02 (2006.01)

Patent

CA 2494546

The compounds of formula (I) are substituted glycine derivatives useful in the treatment of epilepsy, faintness attacks, hypokinesia, cranial disorders, neurodegenerative disorders, depression, anxiety, panic, pain, arthritis, neuropathological disorders, sleep disorders, visceral pain disorders and gastrointestinal disorders. Processes for the preparation of the final products and intermediates useful in the process are included. Pharmaceutical compositions containing one or more of the compounds are also included. Formula (I) wherein R' is hydroxycarbonyl, a carboxylic acid biostere or prodrug thereof; R3, R3a, R2 and R2a are independently selected from H, C1-C6 alkyl, and Cl-C6 alkoxy Cl-C6 alkyl.

La présente invention concerne des composés de formule (I) qui sont des dérivés de glycine substitués utilisés pour traiter l'épilepsie, des pertes de connaissance, une hypocinésie, des troubles crâniens, des troubles neurodégénératifs, une dépression, l'anxiété, la panique, la douleur, l'arthrite, des troubles neuropathologiques, des troubles du sommeil, des troubles de douleur viscérale et des troubles gastro-intestinaux. La présente invention concerne également des procédés pour préparer les produits finaux et les produits intermédiaires utilisés dans ledit procédé. En outre, cette invention concerne des compositions pharmaceutiques contenant un ou plusieurs desdits composés. Formule (I) R?1¿ représente hydroxycarbonyle, un biostère d'acide carboxylique ou un médicament de celui-ci; R?3¿, R?3a¿, R?2¿ et R?2a¿ sont choisis indépendamment parmi H, alkyle C¿1?-C¿6? et alkyle C¿1?-C¿6? alkoxy C¿1?-C¿6?

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