Protein design automation for designing protein libraries...

Details Protein design automation for designing protein libraries... Protein design automation for designing protein libraries...

G - Physics

06

F

G06F 17/50 (2006.01) C07K 1/00 (2006.01) G06F 19/00 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2415902

The present invention relates to the use of a variety of computational methods for modulating the immunogenicity of proteins by identifying and then altering potential amino acid sequences that elicit an immune response in a host organism. In particular, protein will be screened for MHC binding sequences, T cell epitopes and B cell epitopes.

L'invention concerne l'utilisation d'un éventail de procédés de calcul pour la modulation de l'antigénicité de protéines, à travers l'identification puis la modification de séquences d'acides aminés potentielles qui induisent une réponse immunitaire dans un organisme hôte. En particulier, on effectue un criblage des protéines visant à déterminer les séquences de liaison du CMH, les épitopes de lymphocytes T et les épitopes de lymphocytes B.

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