New 9-chloro-prostaglandin derivatives

Details New 9-chloro-prostaglandin derivatives New 9-chloro-prostaglandin derivatives

C - Chemistry, Metallurgy

07

C

C07C 405/00 (2006.01) A61K 31/557 (2006.01) A61K 31/715 (2006.01) A61K 31/724 (2006.01) A61K 47/48 (2006.01) C08B 37/16 (2006.01)

Patent

CA 2170613

The invention relates to 9-chloro-prostaglandin derivatives of formula I Image (I), in which X means oxygen or CH2, R1 means hydrogen or straight-chain or branched alkyl with 1-6 C atoms and A means trans-CH=CH- or -CH2-CH2-, as well as their salts with physiologically compatible bases, if R1 represents hydrogen, and their clathrates with .alpha.-, .beta.- or .gamma.- cyclodextrin, process for their production and their pharmaceutical use.

L'invention concerne des dérivés de 9-chloroprostaglandine de la formule (I), dans laquelle X désigne oxygène ou CH2, R<1> désigne hydrogène ou alkyle à chaîne droite ou ramifiée ayant 1 à 6 atomes de carbone et A désigne trans-CH=CH- ou -CH2-CH2-, leurs sels avec des bases physiologiquement neutres, lorsque R<1> désigne hydrogène, et leurs clathrates avec la cyclodextrine alpha , beta ou gamma , ainsi que leur procédé de préparation et leur utilisation pharmaceutique.

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