C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/54 (2006.01) A61K 31/706 (2006.01) A61K 38/45 (2006.01) A61P 35/00 (2006.01) C12N 9/12 (2006.01) A61K 48/00 (2006.01)
Patent
CA 2609633
The present invention relates to isolated nicotinamide riboside kinase (Nrk) nucleic acid sequences, vectors and cultured cells containing the same, and Nrk polypeptides encoded thereby. Methods for identifying individuals or tumors susceptible to nicotinamide riboside-related prodrug treatment and methods for treating cancer by administering an Nrk nucleic acid sequence or polypeptide in combination with a nicotinamide riboside-related prodrug are also provided. The present invention further provides screening methods for isolating a nicotinamide riboside-related prodrug and identifying a natural source of nicotinamide riboside.
La présente invention concerne des séquences d'acides nucléiques de nicotinamide riboside kinase (Nrk), des vecteurs et des cellules cultivées les contenant et des polypeptides Nrk ainsi codés. Ladite invention a, également, pour objet des méthodes d'identification d'individus ou de tumeurs susceptibles de suivre un traitement au promédicament associé à la nicotinamide riboside, et des méthodes de traitement d'un cancer par administration d'un polypeptide ou d'une séquence d'acides nucléiques Nrk en combinaison avec un promédicament lié à la nicotinamide riboside. Cette invention a, aussi, trait à des méthodes de criblage permettant d'isoler un promédicament associé à la nicotinamide riboside et d'identifier une source naturelle de nicotinamide riboside.
Borden Ladner Gervais Llp
Trustees Of Dartmouth College
LandOfFree
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