Substituted imidazoles having anti-cancer and cytokine...

Details Substituted imidazoles having anti-cancer and cytokine... Substituted imidazoles having anti-cancer and cytokine...

C - Chemistry, Metallurgy

07

D

C07D 417/14 (2006.01) A61K 31/445 (2006.01) A61K 31/495 (2006.01) A61K 31/53 (2006.01) A61K 31/535 (2006.01) C07D 401/14 (2006.01) C07D 405/14 (2006.01) C07D 413/14 (2006.01)

Patent

CA 2234066

Compounds represented by formula (I), are disclosed. AR represents an aromatic group containing 6-10 atoms; and (a) represents a 4 to membered non-aromatic heterocycle containing at least one N atom, and optionally containing 1-2 additional N atoms and 0-1 O or S atom. A pharmaceutical composition is also included. Methods of treating cancer and cytokine mediated diseases are also included.

L'invention porte sur des composés représentés par la formule (I), dans laquelle <AR> représente un groupe aromatique contenant de 6 à 10 atomes; et (a) représente un hétérocycle non-aromatique de 4 à 10 chaînons contenant au moins un atome N, et contenant facultativement de 1 à 2 atomes N supplémentaires et de 0 à 1 atome O ou S. L'invention porte également sur une composition pharmaceutique, et sur des méthodes de traitement du cancer et de maladies véhiculées par la cytokine.

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