Compositions and methods for the therapy and diagnosis of...

C - Chemistry – Metallurgy – 12 – N

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C12N 15/31 (2006.01) C12N 5/0781 (2010.01) C12N 5/0783 (2010.01) A61K 31/7088 (2006.01) A61K 35/12 (2006.01) A61K 39/00 (2006.01) A61K 39/02 (2006.01) A61K 39/395 (2006.01) A61P 1/00 (2006.01) A61P 29/00 (2006.01) A61P 31/04 (2006.01) C07H 21/00 (2006.01) C07K 14/195 (2006.01) C07K 16/12 (2006.01) C12N 15/11 (2006.01) C12N 15/63 (2006.01) C12Q 1/02 (2006.01) C12Q 1/68 (2006.01) G01N 33/53 (2006.01) G01N 33/564 (2006.01) G01N 33/569 (2006.01) G01N 33/68 (2006.01) C07K 14/205 (2006.01)

Patent

CA 2476755

Compositions and methods for the therapy and diagnosis of Inflammatory Bowel Disease (IBD), including Crohn~s Disease and Ulcerative Colitis, are disclosed. Illustrative compositions comprise one or more bacterial polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of IBD.

L'invention concerne des compositions et des procédés applicables à la thérapie et au diagnostic pour la maladie intestinale inflammatoire, y compris la maladie de Crohn et la colite ulcéreuse. Par exemple, l'invention concerne des compositions qui renferment un ou plusieurs polypeptides bactériens, des parties immunogènes correspondantes, des polynucléotides codant ces polypeptides, et des lymphocytes T spécifiques aux cellules exprimant les polypeptides en question. Les compositions décrites sont utiles, par exemple, pour le diagnostic, la prévention et/ou le traitement de la maladie intestinale inflammatoire.

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