C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 14/705 (2006.01) A61K 38/17 (2006.01) A61P 37/00 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2405484
The present invention is directed to the treatment of autoimmune diseases, in particular of Myasthenia Gravis. This invention provides novel autoimmune dominant peptides derived from the acetylcholine receptor, as well as methods for preparing the peptides. The present invention further provides complexes comprising these peptides associated with an appropriate major histocompatibility complex (MHC) molecule and methods for making these complexes. The complexes of the present invention can be used therapeutically or prophylactically for treating Myasthenia Gravis.
La présente invention concerne le traitement de maladies auto-immunes, et notamment de la myasthénie grave. Elle se rapporte à des nouveaux peptides dominants auto-immuns issus du récepteur de l'acétylcholine, ainsi qu'à des méthodes de préparation de ces peptides. La présente invention concerne également des complexes comprenant ces peptides associés à une molécule de complexe majeur d'histocompatibilité (CMH) appropriée, ainsi que des méthodes de préparation de ces complexes. Les complexes de la présente invention peuvent être utilisés de manière thérapeutique ou prophylactique pour traiter la myasthénie grave.
Arimilli Subhashini
Deshpande Shrikant
Spack Edward
Wehner Nancy
Ade & Company
Corixa Corporation
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