Pharmaceutical formulations of antineoplastic agents, in...

Details Pharmaceutical formulations of antineoplastic agents, in... Pharmaceutical formulations of antineoplastic agents, in...

A - Human Necessities

61

K

A61K 9/08 (2006.01) A61K 9/19 (2006.01) A61K 31/395 (2006.01) A61K 31/4188 (2006.01) A61K 47/18 (2006.01)

Patent

CA 2476494

In its several embodiments, this invention discloses a pharmaceutical formulation comprising at least one antineoplastic agent or a pharmaceutically acceptable salt thereof, and at least one dissolution enhancing agent sufficient to substantially dissolve said at least one antineoplastic agent in at least one aqueous diluent, wherein said dissolution enhancing agent is urea, L-histidine, L-threonine, L-asparagine, L-serine, L-glutamine or mixtures thereof; a lyophilized powder comprising said pharmaceutical formulation, and articles of manufacture thereof.

Plusieurs modes de réalisation de l'invention concernent une formulation pharmaceutique comprenant au moins un agent anti-néoplastique ou un sel acceptable sur le plan pharmaceutique de celui-ci et au moins un agent favorisant la dissolution permettant de dissoudre sensiblement ledit agent anti-néoplastique dans au moins un diluent aqueux, l'agent favorisant la dissolution pouvant être de l'urée, de la L-histidine, de la L-thréonine, de la L-asparagine, de la L-sérine, de la L-glutamine ou des mélanges de ces produits. L'invention concerne également une poudre lyophilisée renfermant ladite formulation pharmaceutique et des articles fabriqués associés.

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