G - Physics – 01 – N
Patent
G - Physics
01
N
G01N 21/33 (2006.01) G01N 21/31 (2006.01) G01N 21/35 (2006.01) G01N 21/39 (2006.01) G01N 21/85 (2006.01) G01N 33/15 (2006.01) G01J 3/02 (2006.01) G01J 11/00 (2006.01)
Patent
CA 2426454
The present invention relates to a method and apparatus for monitoring characteristics of a pharmaceutical composition during preparation thereof by in the process vessel (1) of a fluidized bed apparatus, wherein a measuring device (11, 11') performs a spectometric measurement on the pharmaceutical composition in a wetting zone (B) into which a processing fluid is injected. The method also comprises the generic use of an optical probe device in spectrometric measurements, the probe device being capable of transmitting a two-dimensional image of radiation emitted from a monitoring area in the process vessel (1).
L'invention concerne un procédé et un appareil permettant de contrôler les caractéristiques d'une composition pharmaceutique durant sa préparation, dans le récipient de traitement (1) d'un appareil à lit fluidisé, procédé selon lequel un dispositif de mesure (11, 11') effectue une mesure spectrométrique sur la composition pharmaceutique dans une zone de mouillage (B) dans laquelle un fluide de traitement est injecté. Le procédé comprend en outre l'utilisation d'un dispositif à sonde optique pour des mesures spectrométriques, le dispositif à sonde étant capable de transmettre une image bidimensionnelle du rayonnement émis à partir d'une aire de contrôle dans le récipient de traitement (1).
Folestad Staffan
Johansson Jonas
Niklasson Bjorn Ingela
Astrazeneca Ab
Fetherstonhaugh & Co.
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