C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) A61K 31/7088 (2006.01) A61K 35/76 (2006.01) A61K 38/17 (2006.01) A61K 45/00 (2006.01) A61K 48/00 (2006.01) A61P 11/06 (2006.01) A61P 37/08 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) C12Q 1/68 (2006.01) G01N 33/53 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2441417
The present invention relates to human secreted polypeptides, and isolated nucleic acid molecules encoding said polypeptides, useful for diagnosing and treating allergic and asthmatic disorders. Antibodies that bind these polypeptides are also encompassed by the present invention. Also encompassed by the invention are vectors, host cells, and recombinant and synthetic methods for producing said polypeptides, and/or antibodies. The invention further encompasses screening methods for identifying agonists and antagonists of polynucleotides and polypeptides of the invention. The present invention further encompasses methods and compositions for inhibiting or enhancing the production and function of the polypeptides of the present invention.
La présente invention concerne des polypeptides sécrétés par les humains, des molécules d'acides nucléiques isolés codant ces polypeptides et convenant pour le diagnostic et le traitement de troubles allergiques et asthmatiques. L'invention concerne également des anticorps se liant à ces polypeptides. L'invention concerne aussi des vecteurs, des cellules hôtes, et des procédés de recombinaison et de synthèse permettant la production de ces polypeptides et/ou anticorps. L'invention concerne en outre des procédés de criblage permettant d'identifier des agonistes et antagonistes des polynucléotides et polypeptides de l'invention. L'invention concerne enfin des procédés et compositions visant à bloquer ou renforcer la production et les fonctions de ces mêmes polypeptides.
Rosen Craig A.
Ruben Steven M.
Human Genome Sciences Inc.
Mbm Intellectual Property Law Llp
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