Methods for treating and preventing gi syndrome and graft...

Details Methods for treating and preventing gi syndrome and graft... Methods for treating and preventing gi syndrome and graft...

C - Chemistry, Metallurgy

07

K

C07K 16/44 (2006.01) A61K 31/55 (2006.01) A61K 31/7088 (2006.01) A61K 38/00 (2006.01) A61K 39/395 (2006.01) A61P 37/06 (2006.01)

Patent

CA 2686722

We have discovered that administering anti-ceramide antibody treats and prevents an array of diseases mediated by cytolytic T lymphocyte (CTLs)-induced killing and by damage to endothelial microvasculture, including radiation-induced GI syndrome, Graft vs. Host diseases, inflammatory diseases and autoimmune diseases. We have also discovered new anti-ceramide monoclonal antibodies, that have therapeutic use preferably in humanized form to treat or prevent these diseases.

L'invention concerne l'administration d'anticorps anticéramides pour traiter et empêcher un large éventail de pathologies provoquées par la destruction induite par le lymphocyte T cytolytique (CTL) - et par des dommages à la microvascularisation endothéliale, y compris le syndrome GI induit par un rayonnement, la réaction de greffe contre l'hôte, les maladies inflammatoires et les maladies auto-immunes. Nous avons également découverts de nouveaux anticorps monoclonaux anticéramides, qui ont une utilisation thérapeutique, de préférence dans la forme humanisée, pour traiter ou prévenir ces maladies.

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