Human monoclonal antibodies that specifically bind igf-ii

Details Human monoclonal antibodies that specifically bind igf-ii Human monoclonal antibodies that specifically bind igf-ii

C - Chemistry, Metallurgy

07

K

C07K 16/26 (2006.01) A61K 39/395 (2006.01) G01N 33/574 (2006.01)

Patent

CA 2618920

Disclosed herein are isolated monoclonal human antibodies that specifically bind insulin-like growth factor II (IGF-II) with an equilibrium dissociation constant (Kd) of 1 nM or less, wherein the antibodies bind IGF-I with an equilibrium dissociation constant (Kd) of 1 mM or greater. The antibodies inhibit phosphorylation of the insulin-like growth factor receptor. Nucleic acids encoding these antibodies, expression vectors including these nucleic acids, and isolated host cells that express the nucleic acids are also disclosed. The antibodies can be used to detect human IGF-II in a sample. Methods of diagnosing a tumor are disclosed herein that utilize these antibodies. Methods of treating a subject with a tumor are also disclosed.

L'invention concerne des anticorps humains monoclonaux isolés qui lient spécifiquement le facteur de croissance ressemblant à l'insuline II (IGF-II) avec une constante de dissociation à l'équilibre (Kd) inférieure ou égale à 1 nM, lesdits anticorps liant l'IGF-I avec une constante de dissociation à l'équilibre (Kd) supérieure ou égale à 1 mM. Les anticorps inhibent la phosphorylation du récepteur du facteur de croissance ressemblant à l'insuline. L'invention concerne également des acides nucléiques codant pour ces anticorps, des vecteurs d'expression incluant ces acides nucléiques et des cellules hôtes isolées qui expriment les acides nucléiques. On peut utiliser les anticorps pour détecter l'IGF-II humain dans un échantillon. L'invention concerne en outre des procédés de diagnostic d'une tumeur qui utilisent ces anticorps, ainsi que des procédés de traitement d'un sujet ayant une tumeur.

Affiliated with

Also associated with

Rating

Human monoclonal antibodies that specifically bind igf-ii does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Human monoclonal antibodies that specifically bind igf-ii, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Human monoclonal antibodies that specifically bind igf-ii will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1981236