Detection of malignant and premalignant conditions

Details Detection of malignant and premalignant conditions Detection of malignant and premalignant conditions

G - Physics

01

N

G01N 33/50 (2006.01) G01N 33/574 (2006.01)

Patent

CA 2120129

2120129 9306485 PCTABS00021 A method of testing for a malignant or pre-malignant condition of the cervix by examination of a cervical cell sample, in which the test is performed on a fraction of the sample consisting predominantly of epithelial cells, which have been separated by a buoyant density method such as a discontinuous density gradient centrifugation. Following separation of the epithelial cells the cells are tested for an abnormal level of an enzyme associated with proliferating cells. Typically, the enzyme tested for is one selected from the group consisting of pentose phosphate shunt enzymes, ornithine decarboxylase, thymidine kinase, and ribonucleotide reductase, e.g. glucose-6-phosphate dehydrogenase and/or 6-phosphogluconate dehydrogenase.

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