C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/13 (2006.01) A61K 39/395 (2006.01) C07K 16/30 (2006.01) C07K 16/46 (2006.01) C07K 19/00 (2006.01) C12N 5/10 (2006.01) A61K 48/00 (2006.01)
Patent
CA 2510180
The invention provides humanized antibody H14.18 binding the human cell surface glycosphingolipid GD2. The antibody comprises modified variable regions, more specially, modified framework regions, which reduce their immunogenitity when administered to a human. The antibody may be coupled to the therapeutic agent such as IL-2 and used in the treatment of cancer.
L'invention concerne l'anticorps humanisé H14.18 se liant au glycosphingolipide humain de surface GD2. Cet anticorps comprend des régions variables modifiées, plus particulièrement des régions de charpente modifiées, qui permettent d'obtenir une réduction de l'immunogénicité en cas d'administration à un être humain. Ledit anticorps peut être couplé à un agent thérapeutique tel que IL-2 et utilisé en traitement du cancer.
Gillies Stephen D.
Lo Kin-Ming
Fetherstonhaugh & Co.
Merck Patent Gesellschaft Mit Beschraenkter Haftung
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