Immunocompromised rodents as dual color tumor models

C - Chemistry – Metallurgy – 12 – Q

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C12Q 1/00 (2006.01) A01K 67/027 (2006.01) G01N 33/00 (2006.01) G01N 33/15 (2006.01)

Patent

CA 2515203

Immunocompromised rodents that have been modified to express a fluorescent protein in substantially all tissues are described. These rodents are useful as models for gene expression, tumor progression and angiogenesis. Also provided are model systems where heterologous tissues fluorescing in a first color are transplanted into hosts that have been modified to fluoresce in substantially all tissues with a second color.

L'invention concerne des rongeurs immunodéprimés ayant été modifiés en vue d'exprimer une protéine fluorescente dans presque tous les tissus. Ces rongeurs sont utiles en tant que modèles pour l'expression génique, la progression tumorale et l'angiogenèse. L'invention concerne également des systèmes de modèles dans lesquels des tissus hétérologues qui émettent une fluorescence d'une première couleur sont transplantés dans des hôtes ayant été modifiés de manière à fluorescer dans presque tous les tissus dans une seconde couleur.

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