Methods and compositions for delivering polynucleotides

A - Human Necessities – 61 – K

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A61K 38/00 (2006.01) A01N 37/18 (2006.01) A01N 43/04 (2006.01) C07H 21/02 (2006.01) C12N 15/00 (2006.01) C12N 15/63 (2006.01) C12P 21/06 (2006.01)

Patent

CA 2543257

Methods and compositions for delivering polynucleotides are provided. One embodiment provides a non-viral vector comprising a recombinant polynucleotide- binding protein comprising a protein transduction domain operably linked to a targeting signal. Methods for modifying the genome of non-nuclear organelles are also provided.

L'invention porte sur des procédés et des compositions permettant de distribuer des polynucléotides. Dans un mode de réalisation, un vecteur non-viral contient une protéine à liaison polynucléotidique recombinante comprenant un domaine de transduction de protéines relié opérationnellement à un signal de ciblage. L'invention concerne aussi des procédés de modification du génome d'organites non-nucléaires.

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