A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/435 (2006.01) A61K 31/4406 (2006.01) A61K 31/4412 (2006.01) A61K 31/505 (2006.01) A61K 31/513 (2006.01) A61P 29/02 (2006.01) A61P 37/06 (2006.01)
Patent
CA 2370206
Pharmaceutical compositions incorporate compounds that affect cytokine production and/or secretion. Such compounds include aryl substituted olefinic amine compounds, pyridyloxylalkylamines and phenoxyalkylamines, and aryl substituted amine compounds, such as 3-aminophenyl amine compounds. Such pharmaceutical compositions can be used for treating a wide variety of conditions, diseases and disorders, and particularly those associated with dysfunction of cytokine production and/or secretion. Of particular interest are pharmaceutical compositions useful for preventing and treating conditions, diseases and disorders associated with undesirably high levels of cytokine production and/or secretion. Such pharmaceutical compositions are useful for treating the effects of inflammatory bowel disease, inflammation, arthritis, cachexia in neoplastics diseases or associated with AIDS, and autoimmune diseases.
La présente invention concerne des compositions pharmaceutiques comprenant des composés qui agissent sur la production et/ou la sécrétion de cytokine. Ces composés comprennent des composés aminés oléfiniques à substitution aryle, des pyridyloxylalkylamines et des phénoxyalkylamines, et des composés aminés à substitution aryle, tels que des composés aminés 3-aminophényle. Ces compositions pharmaceutiques peuvent être utilisées pour traiter une grande variété d'états, de maladies et de troubles, en particulier les troubles associés au dysfonctionnement de la production et/ou de la sécrétion de cytokine. Des compositions pharmaceutiques qui conviennent pour la prévention et le traitement d'états, de maladies et de troubles liés à des niveaux élevés indésirables de production et/ou de sécrétion de cytokine, présentent un intérêt particulier. Ces compositions pharmaceutiques sont utiles pour traiter les effets de maladies entériques inflammatoires, les inflammations, l'arthrite, la cachexie liée aux affections néoplasiques ou au SIDA, et les maladies auto-immunes.
Robic
Targacept Inc.
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