Modulating interstitial pressure and oncolytic viral...

Details Modulating interstitial pressure and oncolytic viral... Modulating interstitial pressure and oncolytic viral...

A - Human Necessities

61

K

A61K 35/76 (2006.01) A61K 31/337 (2006.01) A61K 31/436 (2006.01) A61K 31/555 (2006.01) A61K 31/675 (2006.01) A61K 38/20 (2006.01) A61K 41/00 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2723580

Provided herein are methods of treating a proliferative disorder in a subject comprising decreasing interstitial pressure and/or increasing vascular permeability in the subject and administering to the subject an oncolytic virus. Such methods improve oncolytic viral delivery and distribution.

L'invention concerne des méthodes de traitement d'un trouble prolifératif chez un sujet, qui consistent à faire baisser la pression interstitielle et/ou à augmenter la permeabilité vasculaire chez le sujet; et à administrer au sujet un virus oncolytique. Lesdites méthodes améliorent l'administration et la distribution de virus oncolytiques.

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