Topiramate salts and compositions comprising and methods of...

C - Chemistry – Metallurgy – 07 – D

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C07D 493/14 (2006.01) A61K 31/35 (2006.01) A61P 25/00 (2006.01) C07H 5/04 (2006.01) C07H 5/06 (2006.01) C07H 9/04 (2006.01)

Patent

CA 2476422

The invention encompasses novel salts of topiramate, and pharmaceutically acceptable polymorphs, solvates, hydrates, dehydrates, co-crystals, anhydrous, or amorphous forms thereof, as well as pharmaceutical compositions and pharmaceutical unit dosage forms containing the same. In particular, the invention encompasses pharmaceutically acceptable salts of topiramate, including without limitation topiramate sodium, topiramate lithium, topiramate potassium, or polymorphs, solvates, hydrates, dehydrates, co-crystals, anhydrous, and amorphous forms thereof. The invention further encompasses novel co-crystals or complexes of topiramate, as well as pharmaceutical compositions comprising them. The invention also encompasses methods of treating or preventing a variety of diseases and conditions including, but not limited to, seizures, epileptic conditions, tremors, cerebral function disorders, obesity, neuropathic pain, affective disorders, tobacco cessation, migraines, and cluster headache.

L'invention concerne de nouveaux sels de topiramate et des polymorphes, solvates, solvates, hydrates, substances déshydratées, co-cristals, formes anhydres ou amorphes pharmaceutiquement acceptables de ces derniers ainsi que des compositions pharmaceutiques et des formes posologiques de produits pharmaceutiques contenant ces derniers. Ladite invention concerne, en particulier, des sels pharmaceutiquement acceptables de topiramate, y compris entre autres topiramate sodium, topiramate lithium, topiramate potassium, ou des polymorphes, solvates, hydrates, substances déshydratées, co-cristals, formes anhydres et amorphes de ces derniers. Cette invention concerne, en outre, de nouveaux co-cristals ou complexes de topiramate et des compositions pharmaceutiques contenant ces derniers ainsi que des méthodes de traitement ou de prévention d'une variété de maladies et d'états pathologiques, y compris entre autres les crises, les états épileptiques, les tremblements, les troubles de la fonction cérébrale, l'obésité, la douleur neuropathique, les troubles affectifs, la cessation du tabac, les migraines et la céphalée vasculaire de Horton.

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