Nanoparticulate formulations of modafinil

A - Human Necessities – 61 – K

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Details

A61K 31/165 (2006.01) A61K 9/14 (2006.01) A61K 9/20 (2006.01) A61P 25/00 (2006.01)

Patent

CA 2657409

The present invention is directed to compositions comprising a nanoparticulate modafinil compositions, or a salt(s), or an enantiomer(s), or a prodrug(s), or a polymorph(s) or derivative thereof, having improved bioavailability. The nanoparticulate modafinil composition formulation particles of the composition have an effective average particle size of less than about 2000 nm and are useful in the treatment of dyssomnias, including but not limited to, narcolepsy, chronic fatigue, eating disorders, compulsive behaviors, ADHD, addictions, substance abuse, sleepiness, nervous system diseases, conditions, syndromes, and symptoms and related diseases, conditions, and symptoms.

La présente invention concerne des compositions comprenant des compositions de nanoparticules de modafinil, ou un (des) sel(s), ou un (des) énantiomère(s), ou un (des) médicament(s) précurseur(s), ou un polymorphe ou dérivé de ceux-ci, ayant une biodisponibilité améliorée. Les particules de la formulation de composition de nanoparticules de modafinil de la composition ont une taille de particule moyenne efficace inférieure à environ 2000 nm et sont utiles dans le traitement des dyssomnies, y compris, sans y être limités, la narcolepsie, la fatigue chronique, les troubles de l'appétit, les comportements compulsifs, l'ADHD, les addictions, l'abus de substances, la somnolence, les maladies du système nerveux, les conditions, les syndromes et les symptômes, ainsi que les maladies, conditions et symptômes correspondants.

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