C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 255/60 (2006.01) A61K 31/165 (2006.01) A61K 31/277 (2006.01) C07C 233/65 (2006.01) C07C 235/84 (2006.01)
Patent
CA 2424396
The present invention discloses novel naphthylsalicylanilides of the general formula (I) wherein W is a substituted or unsubstituted naphthyl ring. The substitution on W includes replacing one or more -H with -OH, alkyl O-alkyl, branched alkyl, or cycloalkyl, containing 1-6 carbon atoms or combinations thereof. Y is a substituted or unsubstituted phenyl ring or substituted or unsubstituted naphthyl ring. The substitution for Y includes replacement of one or more -H atoms with Cn, CF3, NO2, methoxy, benzoyl, phenoxy, phenoxymethyl or combinations thereof. These compounds are useful as antibacterial against gram negative and gram positive bacteria and as antiinflammatory agents.
L'invention concerne de nouveaux naphthylsalicylanilides représentés par la formule générale (I) dans laquelle W représente un cycle naphtyle substitué ou non. La substitution sur W consiste à remplacer un ou plusieurs -H par -OH, alkyle, O-alkyle, alkyle ramifié, ou cycloalkyle, contenant entre 1 et 6 atomes de carbone, ou par des combinaisons de ceux-ci. Y représente un cycle phénylique substitué ou non, ou un cycle naphtyle substitué ou non. La substitution de Y consiste à remplacer un ou plusieurs atomes -H par CN, CF¿3?, NO¿2?, méthoxy, benzoyle, phénoxy, phénoxyméthyle, ou par des combinaisons de ceux-ci. Ces composés sont utilisés comme agents antibactériens agissant contre les bactéries à gram négatif et à gram positif, et comme agents anti-inflammatoires.
Coburn Robert A.
Evans Richard T.
Genco Robert J.
Gowan Intellectual Property
The Research Foundation Of State University Of New York
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