C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 5/065 (2006.01) A61K 31/395 (2006.01) A61K 31/445 (2006.01) A61K 31/55 (2006.01) A61K 38/05 (2006.01) C07D 205/04 (2006.01) C07D 207/16 (2006.01) C07D 211/60 (2006.01) C07D 223/06 (2006.01)
Patent
CA 2223500
The present invention is directed to novel compounds that are thrombin inhibitors and are useful for the treatment of arterial and venous thrombotic occlusive disorders, inflammation, cancer, and neurodegenerative diseases. The compounds have general Formula (I), and parmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, R5, n and m are defined herein.
La présente invention concerne des composés, et certains de leurs sels admis en pharmacologie, présentant un effet inhibiteur de la thrombine et convenant particulièrement au traitement des troubles thrombotiques artériels et veineux occlusifs, des affections inflammatoires, cancéreuses et neurodégénératives. Ces composés sont représentés par la formule générale (I) dans laquelle R?1¿, R?2¿, R?3¿, R?4¿, R?5¿, n et m sont définis dans la demande.
Bone Roger F.
Illig Carl R.
Lu Tianbao
Soll Richard M.
Subasinghe Nalin L.
3-Dimensional Pharmaceuticals Inc.
Mbm & Co.
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