Methods and compositions for reducing uv-induced inhibition...

Details Methods and compositions for reducing uv-induced inhibition... Methods and compositions for reducing uv-induced inhibition...

A - Human Necessities

61

K

A61K 31/20 (2006.01) A61K 8/35 (2006.01) A61K 8/37 (2006.01) A61K 8/67 (2006.01) A61K 31/07 (2006.01) A61K 31/12 (2006.01) A61K 31/165 (2006.01) A61K 31/167 (2006.01) A61K 31/17 (2006.01) A61K 31/185 (2006.01) A61K 31/196 (2006.01) A61K 31/203 (2006.01) A61K 31/235 (2006.01) A61K 31/277 (2006.01) A61K 31/35 (2006.01) A61K 31/352 (2006.01) A61K 31/4439 (2006.01) A61K 31/517 (2006.01) A61K 31/522 (2006.01) A61Q 17/04 (2006.01) A61Q 19/08 (2006.01)

Patent

CA 2326507

Exposure of human skin to ultraviolet (UV) radiation from the sun not only induces the production of enzymes (matrix metalloproteinases) that degrade collagen, but also inhibits the synthesis of new collagen by inhibiting the synthesis of procollagen. This UV-induced inhibition of the synthesis of collagen can be prevented by the topical application of a retinoid or c-JUN inhibitor to the skin prior to its exposure to UV radiation.

L'exposition de la peau humaine au rayonnement ultraviolet (UV) du soleil non seulement réduit la production d'enzymes (métalloprotéases matricielles) dégradant le collagène, mais inhibe également la synthèse de nouveau collagène par inhibition de la synthèse de procollagène. On peut empêcher cette inhibition induite par UV de la synthèse du collagène par l'application topique d'un rétinoïde ou d'un inhibiteur de c-JUN sur la peau avant son exposition à un rayonnement UV.

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