Isolated nucleic acid molecules encoding a bacterial uracil...

Details Isolated nucleic acid molecules encoding a bacterial uracil... Isolated nucleic acid molecules encoding a bacterial uracil...

C - Chemistry, Metallurgy

12

Q

C12Q 1/68 (2006.01) C07H 21/04 (2006.01) C07K 14/195 (2006.01) C07K 14/255 (2006.01) C07K 14/705 (2006.01) C12N 1/21 (2006.01) C12N 5/14 (2006.01) C12N 5/16 (2006.01) C12N 9/10 (2006.01) C12N 15/52 (2006.01) C12N 15/63 (2006.01)

Patent

CA 2461998

Disclosed herein are novel polynucleotides encoding one of a uracil transport protein and a uracil phosphoribosyl transferase, each being derived from Salmonella typhimurium. The disclosed uracil phosphoribosyl transferase protein is useful in sensitizing human cancer cells to treatment with anti- cancer agents such as 5-Fluorouracil.

L'invention concerne des polynucléotides qui codent soit une protéine de transport d'uracil soit une enzyme uracil phosphoribosyl transférase, chacune provenant de la Salmonella typhimurium. L'enzyme uracil phosphoribosyl transférase considérée est utile pour sensibiliser les cellules cancéreuses humaines au traitement à base d'anticancéreux du type 5-Fluorouracil.

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