Sustained release composition for oral administration of drugs

Details Sustained release composition for oral administration of drugs Sustained release composition for oral administration of drugs

A - Human Necessities

61

K

A61K 9/22 (2006.01) A61K 9/00 (2006.01) A61K 31/366 (2006.01) A61K 31/4422 (2006.01) A61K 31/64 (2006.01) A61K 47/36 (2006.01) A61P 9/12 (2006.01)

Patent

CA 2502731

A sustained-release composition for oral administration of a drug, comprising the drug, a mixture of sodium alginate and xanthan gum as a carrier for sustained release and a mixture of hydroxypropyl methylcellulose and propylene glycol alginate as a gel hydration accelerator, which is capable of maintaining a constant drug level in blood for 24 hours or more owing to the fact that the drug release rate follows zero order kinetics and does not significantly vary with the degree of gastrointestinal motility due to rapid gel hydration without forming a non-gelated core.

L~invention concerne une composition à libération prolongée destinée à une administration orale d~un médicament et comprenant le médicament, un mélange d~alginate de sodium et de gomme xanthane utilisée comme véhicule destiné à la libération prolongée et un mélange d~hydroxypropylméthyl cellulose et d~alginate de propylène glycol utilisé comme accélérateur d~hydratation de gel. Cette composition permet de maintenir un niveau constant du médicament dans le sang pendant au moins 24 heures, du fait que la vitesse de libération du médicament suit une cinétique d~ordre zéro et ne varie pas considérablement avec le degré de motilité gastro-intestinale, en raison de l~hydratation de gel rapide sans formation d~un noyau non gélifié.

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