C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 215/56 (2006.01) A61K 31/47 (2006.01) A61P 31/18 (2006.01)
Patent
CA 2566922
The present invention provides a crystal of 6-(3-chloro-2-fluorobenzyl)-1-[(S)- 1-hydroxymethyl-2-methylpropyl]-7-methoxy-4-oxo-1,4-dihydroquinoline-3- carboxylic acid, which shows a particular powder X-ray diffraction pattern of a characteristic diffraction peaks at diffraction angles 2.theta. (~) as measured by powder X-ray diffractometry. The crystal of the present invention is superior in physical and chemical stability.
La présente invention porte sur un cristal d'acide 6-(3-chloro-2-fluorobenzyl)-1-[(S)-1-hydroxyméthyl-2-méthylpropyl]-7-méthoxy-4-oxo-1,4-dihydroquinoline-3-carboxylique, qui présente un profil particulier de diffraction des rayons X sur poudres comportant des pics de diffraction caractéristiques à des angles de diffraction de 2.theta. (·), la mesure étant effectuée par diffractométrie X sur poudres. Le cristal de la présente invention possède une stabilité physique et chimique supérieure à celle des cristaux de la technique antérieure.
Ando Koji
Kondo Kentaro
Matsuda Koji
Matsuda Takashi
Miyake Shuji
Japan Tobacco Inc.
Ridout & Maybee Llp
LandOfFree
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