A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/16 (2006.01) A61K 39/00 (2006.01) C07K 14/00 (2006.01)
Patent
CA 2469092
A vaccine for reducing disease progression, and/or protection of motor nerve degeneration, and/or protection from glutamate toxicity in motor neurone disease (MND), particularly amyotrophic lateral sclerosis (ALS), patients, comprising an active agent selected from the group consisting of Cop 1, a Cop 1-related peptide, a Cop 1-related polypeptide, and poly-Glu,Tyr. The active agent is preferably Cop 1 or poly-Glu,Tyr, and can be administered with or without an adjuvant.
L'invention concerne un vaccin destiné à ralentir la progression d'une maladie et/ou à prévenir la dégénérescence des nerfs moteurs et/ou à fournir une protection contre la toxicité du glutamate chez des patients présentant une maladie du motoneurone (MND), et notamment une sclérose latérale amyotrophique (SLA). Ce vaccin comprend un agent actif choisi dans le groupe constitué par Cop 1, un peptide associé à Cop-1, un polypeptide associé à Cop 1, et poly-Glu,Tyr. L'agent actif est de préférence Cop 1 ou poly-Glu,Tyr, et peut être administré avec ou sans adjuvant.
Eisenbach-Schwartz Michal
Yoles Esther
Heenan Blaikie Llp
Yeda Research And Development Co. Ltd
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