Preparation of dicarboxylic acid monoesters from...

C - Chemistry – Metallurgy – 12 – N

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C12N 9/78 (2006.01) C12P 7/44 (2006.01) C12P 7/62 (2006.01)

Patent

CA 2416429

This invention relates to a process for preparing dicarboxylic acid monoesters from cyanocarboxylic acid esters. More particularly, using the nitrilase from Acidovorax facilis 72W (ATCC 55745) in various forms as an enzyme catalyst, an aliphatic or aromatic cyanocarboxylic acid ester is converted to the corresponding dicarboxylic acid monoester with high chemoselectivity at 100 % conversion. An embodiment of the invention also provides a process for obtaining high chemoselectively and high regioselectivity.

L'invention concerne un procédé de préparation de monoesters d'acide dicarboxylique à partir d'esters d'acide cyanocarboxylique. Plus particulièrement, grâce à l'utilisation de la nitrilase issue d'Acidovorax facilis 72W (ATCC 55745) sous différentes formes en tant que catalyseur enzymatique, un ester d'acide cyanocarboxylique aliphatique ou aromatique est converti en un monoester d'acide dicarboxylique correspondant avec une chimiosélectivité élevée dans une proportion de 100 %. Dans un mode de réalisation de l'invention, un procédé permet d'obtenir une chimiosélectivité et une régiosélectivité élevées.

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