Antibodies to cytokines in the prevention and treatment of...

Details Antibodies to cytokines in the prevention and treatment of... Antibodies to cytokines in the prevention and treatment of...

A - Human Necessities

61

K

A61K 39/395 (2006.01) C07K 16/00 (2006.01)

Patent

CA 2334471

Methods are described for treating inflammatory bowel disease in animals, including humans. Specific avian polyclonal antibodies directed to proinflammatory cytokines (such as IL-6 and TNF) are shown to have a beneficial effect in animal models predictive of human therapy for the treatment of colitis, including Crohn's disease.

La présente invention concerne un traitement des maladies intestinales inflammatoires chez les animaux, y-compris l'homme. Certains anticorps polyclonaux aviaires dirigés contre des cytokines pro-inflammatoires tels que les interleukines 6 (IL-6) et le facteur de nécrose tumorale (TNF) semblent avoir un effet bénéfique sur des modèles animaux d'étude de la thérapie humaine destiné au traitement des colites, y-compris de la maladie de Crohn.

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