Use of slim-1 in the assessment of heart failure

G - Physics – 01 – N

Patent

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G01N 33/50 (2006.01) G01N 33/53 (2006.01)

Patent

CA 2680339

The invention relates to a method for assessing heart failure in vitro comprising the steps of measuring in a sample the concentration of the marker SLIM-1, of optionally measuring in the sample the concentration of one or more other marker(s) of heart failure, and of assessing heart failure by comparing the concentration determined in for SLIM-1 and the concentration(s) determined for the optionally one or more other marker to the concentration of this marker or these markers as established in a reference population. Also disclosed are the use of SLIM-1 as a marker protein in the assessment of heart failure, a marker combination comprising SLIM-1 and a kit for measuring SLIM-1.

La présente invention concerne un procédé d'évaluation d'insuffisance cardiaque in vitro, comprenant les étapes de mesure dans un échantillon de la concentration d'un marqueur SLIM-1, de la mesure optionnelle dans l'échantillon de la concentration d'un ou de plusieurs autres marqueurs d'insuffisance cardiaque et de l'évaluation d'une insuffisance cardiaque en comparant la concentration déterminée pour SLIM-1 et la concentration déterminée pour le ou les autres marqueurs optionnels à la concentration de ce marqueur ou de ces marqueurs telle qu'elle est établie dans une population de référence. L'invention concerne aussi l'utilisation de SLIM-1 en tant que protéine marqueur dans l'évaluation d'une insuffisance cardiaque, une combinaison de marqueur se composant de SLIM-1 et un kit de mesure de SLIM-1.

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