Virus-like particles as vaccines for paramyxovirus

C - Chemistry – Metallurgy – 12 – N

Patent

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C12N 7/01 (2006.01) A61K 39/00 (2006.01) A61K 39/12 (2006.01) A61P 31/12 (2006.01) A61P 31/14 (2006.01) A61P 37/04 (2006.01) C07K 14/125 (2006.01) C12N 15/00 (2006.01) C12N 15/86 (2006.01) C07K 17/02 (2006.01)

Patent

CA 2715237

The invention provides expression vectors and virus-like particles (VLPs) containing Newcastle Dis-ease Virus Sequences in combination with sequences en-coding proteins of interest. The vectors are useful in, for example, generating virus-like particles (VLPs) that con-tain proteins of interest. In one embodiment, the expressed VLPs elicit an immune response by an animal host against the protein. The invention's VLPs are useful as, for exam-ple, vaccines. (b) its patent agent.

L'invention concerne des vecteurs d'expression et des particules pseudo-virales (VLP) contenant des séquences du virus de la maladie de Newcastle combinées avec des séquences codant des protéines d'intérêt. Les vecteurs sont utilisés, par exemple, pour générer des particules pseudo-virales (VLP) contenant les protéines d'intérêt. Dans un mode de réalisation, les VLP exprimées élicitent une réponse immunitaire par un animal hôte envers la protéine. Les VLP de l'invention servent, notamment, de vaccins.

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