Fluorinated derivatives of deferiprone

Details Fluorinated derivatives of deferiprone Fluorinated derivatives of deferiprone

C - Chemistry, Metallurgy

07

D

C07D 213/69 (2006.01) A61K 31/351 (2006.01) A61K 31/4412 (2006.01) A61P 25/16 (2006.01) A61P 25/28 (2006.01) A61P 39/04 (2006.01) C07D 309/40 (2006.01)

Patent

CA 2681545

The present invention relates to novel derivatives of deferiprone. In particular, the present invention relates to fluorinated derivatives of deferiprone or pharmaceutically acceptable salts thereof, pharmaceutical compositions comprising same, processes for the manufacture thereof and their use in the treatment of neurodegenerative diseases caused by the presence of free iron or iron accumulation in neural tissues and in diseases wherein excess iron must be removed or redistributed.

La présente invention porte sur de nouveaux dérivés de défériprone. En particulier, la présente invention porte sur des dérivés fluorés de défériprone ou sur des sels pharmaceutiquement acceptables de ceux-ci, sur des compositions pharmaceutiques les comprenant, sur des procédés permettant de les fabriquer et sur leur utilisation dans le traitement de maladies neurodégénératives provoquées par la présence de fer libre ou d'accumulation de fer dans les tissus nerveux et de maladies dans lesquelles le fer en excès doit être éliminé ou redistribué.

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