Method to fabricate microcapsules from polymers and charged...

A - Human Necessities – 61 – K

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A61K 9/00 (2006.01) A01N 59/00 (2006.01) A61K 9/14 (2006.01) A61K 9/16 (2006.01) A61K 33/42 (2006.01)

Patent

CA 2558916

A method for making hollow nanoparticles, comprises a) providing an amount of a polyelectrolyte having a charge, b) providing an amount of a counterion having a valence of at least 2, c) combining the polyelectrolyte and the counterion in a solution such that the polyelectrolyte self-assembles to form spherical aggregates, and d) adding nanoparticles to the solution such that nanoparticles arrange themselves around the spherical aggregates. The polyelectrolyte may have a positive or negative charge. The charge ratio R of total charge of the counterions to the total charge of the polyelectrolyte is greater than 1Ø

L'invention concerne un procédé de fabrication de nanoparticules creuses. Ledit procédé consiste : a) à utiliser une quantité d'un polyélectrolyte présentant une charge, b) à utiliser une quantité d'un contre-ion présentant une valence d'au moins 2, c) à combiner le polyélectrolyte et le contre-ion dans une solution de sorte que le polyélectrolyte s'auto-assemble afin de former des agrégats sphériques, et d) à ajouter des nanoparticules dans la solution de sorte que les nanoparticules s'agencent elles-mêmes autour des agrégats sphériques. Le polyélectrolyte peut présenter une charge positive ou négative. Le taux de charge R de la charge totale des contre-ions par rapport à la charge totale du polyélectrolyte est supérieur à 1,0.

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