A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/554 (2006.01) A61P 35/00 (2006.01)
Patent
CA 2373484
The present invention relates to use of compounds represented by the following general formula [1] or salts or prodrugs thereof: <see formula I> [where R1 represents hydrogen atom or lower alkoxy group; RZ represents hydrogen atom, lower alkoxy group, optionally substituted phenyl group, <see formula> (where R3 represents acyl group); X represents -CO- or -CH2-; and n-represents 1 or 2], as drugs for overcoming a resistance to anticancer drugs or drugs for enhancing an effect of anticancer drugs. The compounds represented by the general formula [1] have not only a function of overcoming the resistance to various anticancer drugs but also a function of enhancing the effect of various anticancer drugs to anticancer-drug sensitive cells. Thus, these compounds have excellent effects on resistant cells and also on sensitive cells, and in particular effective in the treatment of a cancer having an acquired resistance to an anticancer drug.
L'invention concerne l'utilisation de composés représentés par la formule générale (I), des sels ou des promédicaments de ceux-ci, en tant que médicaments contre la tolérance carcinostatique ou en tant que médicaments augmentant l'effet d'agents cancérostatiques. Dans ladite formule (I), R<1> représente hydrogène ou alcoxy inférieur; R<2> représente hydrogène, alcoxy inférieur, phényle éventuellement substitué (1), (dans laquelle R<3> représente acyle); X représente -CO- ou -CH2-; et n vaut 1 ou 2. Les composés de formule générale (I) agissent contre la tolérance à divers agents cancérostatiques mais peuvent également augmenter les effets de divers agents cancérostatiques sur des cellules à sensibilité cancérostatique. Ainsi, lesdits composés sont très efficaces sur les cellules tolérantes et les cellules sensibles, notamment dans le traitement de cancer devenu tolérant aux agents cancérostatiques.
Kaneko Noboru
Nakamura Takashi
Nishio Kazuhito
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Kaneko Noboru
LandOfFree
Use of 1,4-benzothiazepine derivatives as drugs for... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Use of 1,4-benzothiazepine derivatives as drugs for..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Use of 1,4-benzothiazepine derivatives as drugs for... will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1991232