Cyclic amidines useful as nmda nr2b antagonists

Details Cyclic amidines useful as nmda nr2b antagonists Cyclic amidines useful as nmda nr2b antagonists

C - Chemistry, Metallurgy

07

D

C07D 417/08 (2006.01) A61K 31/4035 (2006.01) A61K 31/472 (2006.01) C07D 209/04 (2006.01) C07D 209/40 (2006.01) C07D 209/48 (2006.01) C07D 217/04 (2006.01) C07D 217/22 (2006.01) C07D 239/04 (2006.01) C07D 265/20 (2006.01) C07D 403/08 (2006.01) C07D 403/14 (2006.01) C07D 405/08 (2006.01)

Patent

CA 2372492

The invention encompasses novel compounds of Formula (I) as well as a method of treating NMDA mediated diseases comprising administration to a patient in need of such treatment a non-toxic amount of a compound of Formula (I) effective to block the NMDA NR2B receptor sub-unit. The invention also encompasses certain pharmaceutical compositions for the treatment of NMDA mediated diseases comprising compounds of Formula (I) and a pharmaceutically acceptable carrier.

L'invention concerne de nouveaux composés de la formule (I) ainsi qu'un procédé permettant de traiter des maladies induites par le N-méthyl-D-aspartate (NMDA). Ce procédé consiste à administrer à un patient une quantité non toxique d'un composé selon la formule (I) permettant de bloquer la sous-unité du récepteur de NMDA NR2D. La présente invention traite aussi de compositions pharmaceutiques permettant de traiter des maladies induites par le NMDA, comprenant des composés selon la formule (I) et un support pharmaceutiquement acceptable.

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