A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/00 (2006.01) A61K 31/19 (2006.01) A61K 31/44 (2006.01)
Patent
CA 2642273
In recognition of the need to develop novel therapeutic agents and efficient methods for the synthesis thereof, the present invention provides novel bifunctional, trifunctional, or multifunctional compounds for inhibiting histone deacetylases, and pharmaceutically acceptable salts and derivatives thereof. The present invention further provides methods for treating disorders regulated by histone deacetylase activity (e.g., proliferative diseases, cancer, inflammatory diseases, protozoal infections, hair loss, etc.) comprising administering a therapeutically effective amount of an inventive compound to a subject in need thereof. The present invention also provides methods for preparing compounds of the invention.
La présente invention concerne de nouveaux composés bifonctionnels, trifonctionnels ou multifonctionnels destinés à inhiber les histones déacétylases, ainsi que des sels pharmaceutiquement acceptables et des dérivés de ceux-ci. Cette invention répond au besoin de mettre au point de nouveaux agents thérapeutiques et des procédés efficaces pour la synthèse de ceux-ci. En outre, la présente invention fournit des procédés destinés à traiter les troubles régulés par l'activité de l'histone déacétylase (tels que les maladies prolifératives, le cancer, les maladies inflammatoires, les infections protozoaires, l'alopécie etc.). Lesdits procédés comprennent l'administration d'une quantité thérapeutiquement efficace d'un composé de l'invention à un sujet en ayant besoin. La présente invention fournit également des procédés de préparation desdits composés de l'invention.
Bradner James Elliot
Mazitschek Ralph
Schreiber Stuart L.
Tang Weiping
Dana-Farber Cancer Institute Inc.
President And Fellows Of Harvard College
Robic
LandOfFree
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