Aryl phosphate derivatives with selective activity against...

Details Aryl phosphate derivatives with selective activity against... Aryl phosphate derivatives with selective activity against...

A - Human Necessities

61

K

A61K 31/70 (2006.01)

Patent

CA 2489357

Methods and compositions for treating ADV infections and HIV/ADV co-infections by administering an aryl phosphate derivative of d4T having an electron withdrawing substituent on the aryl group and an amino acid substituent on the phosphate group are described. Preferred aryl phosphate derivatives of d4T are d4T-5~-[p-bromophenyl methodyalaninyl phosphate] and d4T-5~-[p-chlorophenyl methoxyalaninyl phosphate].

L'invention concerne des procédés et des compositions destinés à traiter des infections par l'ADV et des co-infections par VIH/ADV par administration d'un dérivé d'aryl phosphate de d4T ayant un substituant de retrait d'électron sur le groupe aryle et un substituant d'acide aminé sur le groupe phosphate. Les dérivés d'aryle phosphate de d4T préférés sont 5'-[p-bromophényle méthoxyalaninyle phosphate] et d4T-5'-[p-chlorophényle méthoxyalaninyle phosphate].

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