Method for determining target protein of drug

Details Method for determining target protein of drug Method for determining target protein of drug

C - Chemistry, Metallurgy

12

Q

C12Q 1/37 (2006.01) G01N 27/26 (2006.01) G01N 33/15 (2006.01) G01N 33/50 (2006.01) G01N 33/53 (2006.01) G01N 33/68 (2006.01) G01N 27/447 (2006.01)

Patent

CA 2458942

A method of determining a target protein of a drug which involves the step of judging a protein showing an increase in its protease sensitivity in the presence of a drug as the target protein of the drug. Using this method, a target protein of a drug can be selected from among, for example, proteins contained in disrupted cell suspension.

L'invention concerne un procédé de détermination d'une protéine cible d'un médicament. Ce procédé consiste à examiner une protéine présentant une augmentation de sa sensibilité à la protéase en présence d'un médicament en tant que protéine cible du médicament. Le procédé selon l'invention permet de sélectionner une protéine cible d'un médicament parmi, par exemple, des protéines contenues dans des suspensions cellulaire interrompues.

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