Targeted liposomal constructs for diagnostic and therapeutic...

A - Human Necessities – 61 – K

Patent

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Details

A61K 9/127 (2006.01) A61K 31/135 (2006.01) A61K 31/70 (2006.01) A61K 45/00 (2006.01) A61K 45/06 (2006.01) A61K 47/00 (2006.01) A61K 47/24 (2006.01) A61K 47/42 (2006.01) A61K 47/48 (2006.01) A61P 3/00 (2006.01)

Patent

CA 2294900

This invention provides a liposomal construct for delivering a diagnostic or therapeutic agent to a mammal comprising a liposomal carrier, a diagnostic or therapeutic agent entrapped within or associated with said liposomal carrier and a sequestering agent distributed within said liposomal carrier to reduce leakage of the diagnostic or therapeutic agent from the liposomal construct prior to delivery.

L'invention concerne un produit de recombinaison liposomique permettant de libérer un agent diagnostique ou thérapeutique dans le corps d'un mammifère. Ce produit de recombinaison comprend un excipient liposomique, un agent diagnostique ou thérapeutique emprisonné dans cet excipient liposomique ou associé à ce dernier, et un agent chélateur réparti à l'intérieur de l'excipient liposomique de manière à réduire les fuites de l'agent diagnostique ou thérapeutique à travers le produit de recombinaison liposomique avant sa libération.

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