Insulinotropic peptide derivatives

Details Insulinotropic peptide derivatives Insulinotropic peptide derivatives

C - Chemistry, Metallurgy

07

K

C07K 14/575 (2006.01) A61K 38/22 (2006.01) A61P 3/10 (2006.01)

Patent

CA 2446394

The present invention relates to the derivates of polypeptide Exendin-4 that can promote the secretion of insulin and are useful in the treatment of diabetes type 2. The amino acid sequence of the derivates is as below: His-Gly- Glu-Gly-Thr-Phe-Thr-Ser-Asp-Leu-Ser-Lys-Gln-X-Glu-Glu-Glu-Ala-Val-Y-Leu-Phe- Ile-Glu-Trp-Leu-Lys-Asn-Gly-Gly-Pro-Ser-Ser-Gly-Ala-Pro-Pro- Pro- Ser-Z. Wherein X is Arg, Leu or Ile, Y is His, Arg or Lys, Z is Arg-OH, -OH, -NH2 or Lys-OH. The derivates could be synthesized by chemical methods or produced by DNA recombinant methods.

Cette invention se rapporte à des dérivés du polypeptide exendine-4 qui peuvent favoriser la sécrétion de l'insuline et qui sont utiles dans le traitement du diabète de type 2. La séquence d'acide aminé de ces dérivés est la suivante: His-Gly-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Leu-Ser-Lys-Gln-X-Glu-Glu-Glu-Ala-Val-Y-Leu-Phe-Ile-Glu-Trp-Leu-Lys-Asn-Gly-Gly-Pro-Ser-Ser-Gly-Ala-Pro-Pro-Pro-Ser-Z, où X représente Arg, Leu ou Ile, Y représente His, Arg ou Lys, Z représente Arg-OH, -OH, -NH¿2? ou Lys-OH. Ces dérivés peuvent être synthétisés par des procédés chimiques ou produits par des techniques de recombinaison d'ADN.

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