Use of (4-alkylpiperazinyl) (phenyl) methanones in the...

Details Use of (4-alkylpiperazinyl) (phenyl) methanones in the... Use of (4-alkylpiperazinyl) (phenyl) methanones in the...

A - Human Necessities

61

K

A61K 31/495 (2006.01) A61P 25/28 (2006.01) C07D 295/18 (2006.01)

Patent

CA 2564068

The invention provides a therapeutic method for treating at least one symptom of Alzheimer~s disease in a mammal, such as a human, wherein the toxicity of a pathogen of .beta. amyloid peptide mammalian cells is implicated and inhibition of the subsequently-induced pathological pathways is desired comprising administering to a mammal in need of such therapy, an effective amount of a benzoylpiperazine derivative, including pharmaceutically acceptable salts thereof.

L'invention porte sur une méthode thérapeutique de traitement d'au moins l'un des symptômes de la maladie d'Alzheimer chez un mammifère tel que l'homme, impliquant la toxicité d'un agent pathogène du peptide ? amyloïde de cellules de mammifères, et l'inhibition des mécanismes pathologiques subséquents. Ladite méthode consiste à administrer à un mammifère le nécessitant une quantité efficace d'un dérivé de la benzoylpipérazine y compris l'un de ses sels pharmacocompatibles.

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