A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 33/10 (2006.01) A61K 31/405 (2006.01) A61K 31/445 (2006.01) A61K 31/522 (2006.01) A61K 31/60 (2006.01)
Patent
CA 2127573
A novel composition of five extant agents was hypothesized, tested, and confirmed for alleviating migraine headaches. The hypothesis was based on ways to correct three features of migraines--falling blood levels of serotonin, vasodilatation, and inflammatory response--using already existing agents. The composition successfully aborted migraines within 30 to 60 minutes, sometimes requiring a repeat four hours later if symptoms returned. Two of the five components--acetylsalicylic acid and caffeine--are already used for treating headaches, yet it was the combination of these two and three other agents--niacin, calcium, and L-tryptophan--that successfully alleviated migraines. Once taken, subjects are not to consume high-potassium food or drinkfor several hours as potassium causes vasodilatation, militating against effortsto enhance vasoconstriction. Other migraine medications risk rebound headaches,serious side effects like cardiac ischemia or paresthesia in the extremities, and drug addiction (some contain a barbiturate and/or narcotic). The five components risk only minor side effects and are used at low-to-very-low doses, further reducing the risk of adverse effects. Apart from occasional flushing from niacin, no side effects or rebound headaches have been reported in migraineurs using this from 1 - 2 1/2 years. No one has previously reported combining these five agents intentionally or serendipitously. No one has reported using tryptophan or calcium for headaches, so the combination of all five agents was not obvious. This migraine treatment resulted from scientific hypothesis-testing, not from serendipity or an "obvious" combining of agents.
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