Cxcl13 antagonists and their use for the treatment of...

Details Cxcl13 antagonists and their use for the treatment of... Cxcl13 antagonists and their use for the treatment of...

A - Human Necessities

61

K

A61K 39/395 (2006.01)

Patent

CA 2646902

Methods of treating disorders related to CXCL13 activity utilize CXCL13 antagonists and, optionally, TNF.alpha. antagonists, such as antibodies, including specified portions or variants, polypeptides, polynucleotides, siRNA, shRNA, ribozymes, and DNAzymes. Disorders related to CXCL13 activity include inflammatory disorders, such as pulmonary disorders, for example, asthma, emphysema, and COPD, and systemic lupus erythematosus.

L'invention concerne des procédés permettant de traiter des troubles liés à l'activité de CXCL13 qui utilisent des antagonistes de CXCL13 et, éventuellement, des antagonistes de TNF.alpha., tels que des anticorps, y compris des parties ou variants spécifiés, des polypeptides, des polynucléotides, des ARNsi, des ARNsh, des ribozymes, et des ADNzymes. Les troubles liés à l'activité de CXCL13 sont notamment des troubles inflammatoires, tels que des troubles pulmonaires, par exemple l'asthme, l'emphysème, et la MPOC, ainsi que le lupus érythémateux disséminé.

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