C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 417/14 (2006.01) A61K 31/404 (2006.01) A61K 31/41 (2006.01) A61K 31/4245 (2006.01) A61K 31/427 (2006.01) A61K 31/4439 (2006.01) A61K 31/454 (2006.01) A61K 31/5377 (2006.01) A61P 3/04 (2006.01) A61P 3/06 (2006.01) A61P 3/10 (2006.01) C07D 209/34 (2006.01) C07D 209/38 (2006.01) C07D 209/40 (2006.01) C07D 211/62 (2006.01) C07D 257/04 (2006.01) C07D 295/096 (2006.01) C07D 307/68 (2006.01) C07D 317/60 (2006.01) C07D 401/02 (2006.01) C07D 401/12 (2006.01) C07D 401/14 (2006.01) C07D 403/02 (2006.01) C07D 403/
Patent
CA 2463615
The present invention is related to the use of oxindole hydrazide derivatives of formula (I) for the treatment and/or prevention of metabolic disorders mediated by insulin resistance or hyperglycemia, comprising diabetes type I and/or II, inadequate glucose tolerance, insulin resistance, hyperlipidemia, hypertriglyceridemia, hypercholesterolemia, obesity, polycystic ovary syndrome (PCOS). In particular, the present invention is related to the use of oxindole hydrazide derivatives of formula (I) to modulate, notably to inhibit the activity of PTPs, in particular of PTP1B, TC-PTP, SHP and GLEPP-1. The present invention is furthermore related to novel oxindole hydrazide derivatives and method of preparation thereof.(I).
L'invention concerne l'utilisation de dérivés oxindoles hydrazides de formule (I) pour le traitement et/ou la prévention de troubles métaboliques médiés par la résistance à l'insuline ou l'hyperglycémie, dont, entre autres, le diabète de type II et/ou II, la tolérance au glucose inappropriée, la résistance à l'insuline, l'hyperlipidémie, l'hypertriglycéridémie, l'hypercholestérolémie, l'obésité, le syndrome des ovaires polykystiques. L'invention porte notamment sur l'utilisation de dérivés oxindoles hydrazides de formule (I) pour moduler, en particulier pour inhiber l'activité de PTP, plus spécifiquement de PTP1B, TC-PTP, SHP et GLEPP-1. L'invention se rapporte également à des nouveaux dérivés oxindoles hydrazides et à leur méthode de préparation.
Bombrun Agnes
Church Dennis
Gerber Patrick
Applied Research Systems Ars Holding N.v.
Kirby Eades Gale Baker
Merck Serono Sa
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