G - Physics – 01 – N
Patent
G - Physics
01
N
G01N 33/543 (2006.01) C07B 61/00 (2006.01) G01N 33/53 (2006.01) G01N 33/58 (2006.01)
Patent
CA 2415098
A combinatorial library comprises a plurality of ligand-bearing support units, where the ligand-bearing support units comprise (a) a solid carrier, (b) one or more ligands covalently bound to the solid carrier, and (c) one or more encoding metal salts impregnated on the support unit, where the distribution of the cations of the encoding metal salts provides a code for identifying the ligand or ligands that are attached to the support units, and the cations have been stabilized against dissolution by treatment with one or more anions that form insoluble or poorly soluble salts of the cations.
Cette invention se rapporte à une bibliothèque combinatoire qui comprend plusieurs unités de supports renfermant des ligands, lesquelles contiennent: (a) un véhicule solide, (b) un ou plusieurs ligands liés par covalence au véhicule solide, et (c) un ou plusieurs sels métalliques de codage imprégnés sur l'unité de support, dans laquelle la distribution des cations des sels métalliques de codage fournit un code permettant d'identifier le ou les ligands qui sont fixés aux unités de support, et dans laquelle les cations ont été stabilisés contre toute dissolution par traitement avec un ou plusieurs anions formant des sels insolubles ou faiblement solubles de ces cations.
Chapman Kevin
Wang Tiebang
Xiong Yusheng
Merck & Co. Inc.
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
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