A - Human Necessities – 01 – N
Patent
A - Human Necessities
01
N
A01N 63/00 (2006.01) C07K 14/00 (2006.01) C07K 14/52 (2006.01) C07K 16/00 (2006.01) C12N 5/00 (2006.01) C12N 15/00 (2006.01) C12P 21/06 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2387808
The present invention relates to a novel CK.beta.-13 protein which is a member of the chemokine family. In particular, isolated nucleic acid molecules are provided encoding the human CK.beta.-13 protein. CK.beta.-13 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of CK.beta.-13 activity. Also provided are diagnostic methods for detecting immune system-related disorders and therapeutic methods for treating immune system-related disorders.
L'invention concerne une nouvelle protéine CK.beta.-13 faisant partie de la famille des chimiokines. Elle porte notamment sur des molécules d'acide nucléique isolées codant pour la protéine CK.beta.-13 humaine. Des polypeptides CK.beta.-13 sont également décrits ainsi que des vecteurs, des cellules hôtes et des méthodes de recombinaison pour la production de ceux-ci. L'invention se rapporte encore à des méthodes de criblage permettant l'identification d'agonistes et d'antagonistes de l'activité de CK.beta.-13 ainsi qu'à des méthodes diagnostiques pour la détection de troubles liés au système immunitaire, et à des méthodes thérapeutiques pour le traitement de troubles relatifs au système immunitaire.
Li Haodong
Luscinskas Francis W.
Seibel George
Ullrich Stephen
Brigham And Women's Hospital Inc.
Human Genome Sciences Inc.
Mbm Intellectual Property Law Llp
Smithkline Beecham Corporation
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