C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 275/28 (2006.01) A61K 31/17 (2006.01) A61K 31/22 (2006.01) A61K 31/27 (2006.01) A61K 31/395 (2006.01) C07C 271/34 (2006.01) C07C 271/46 (2006.01) C07C 275/30 (2006.01) C07C 275/32 (2006.01) C07C 275/34 (2006.01) C07C 323/43 (2006.01) C07C 323/44 (2006.01) C07D 209/08 (2006.01) C07D 213/75 (2006.01) C07D 231/56 (2006.01)
Patent
CA 2116621
The present invention is concerned with novel anticancer agents having potent antineoplastic activity without systemic toxicity and mutagenicity. The novel anticancer agents of the present invention are derivatives of formula I: (see formula I) wherein: A is O or NH; and B is an aryl group selected from the group consisting of phenyl, indane, fluorene, indazole, indole, and pyridine, the aryl group being substituted with at least one substituent selected from the group consisting of hydrogen, C1-16 alkyl optionally substituted with one or more OH or SH, lower alkoxy, C3-6 cycloalkyl, lower alkylthio, nitro, cyano, lower alkene, lower alkyne, OH, SH, carboxy lower alkyl, carboxy lower alkyl esters, amino, N-lower alkyl, N,N-dilower alkyl and halogen; or a prodrug thereof, with the provisos that when A is NH and B is phenyl: a) B is substituted with at least one substituent other than hydrogen; b) B is not: 1) mono-substituted in the 4 position with C1-2 alkyl, tert-butyl or n- butyl, halogen, OH, carboxy C0-3 alkyl, (CH2)3COOCH3, cyano, acetyl and methylthio; and 2) substituted with one or two identical substituents selected from the group consisting of methyl, halogen, nitro, methoxy, carboxy and C0- 3alkyl COON, the remaining substituents being hydrogen atoms.
Gaudreault Rene C.
Poyet Patrick
Goudreau Gage Dubuc
Sovar Societe En Commandite
LandOfFree
Novel anticancer agents does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Novel anticancer agents, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Novel anticancer agents will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1995701