Method for the preparation of n-substituted 4-ketoproline...

C - Chemistry – Metallurgy – 07 – D

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C07D 207/24 (2006.01)

Patent

CA 2180294

Method for the preparation of N-protected 4-ketoproline derivatives of formula I Image Formula I by oxidation of the corresponding N-protected 4- hydroxyproline derivatives of formula III Image Formula III using the system TEMPO (2,2,6,6-tetramethylpiperidinyl oxy free radical)/NaOCl.

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