C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 401/14 (2006.01) A61K 31/4709 (2006.01) C07D 401/06 (2006.01) C07D 409/14 (2006.01)
Patent
CA 2362394
The present invention relates to compounds of formula (1) and pharmaceutically acceptable salts and solvates thereof wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, and Z are as defined herein. The invention also relates to pharmaceutical compositions comprising compounds of formula (1) and to methods of inhibiting abnormal cell growth, including cancer, in a mammal by administering compounds of formula (1) to the mammal. The invention also relates to intermediates and methods useful in synthesizing compounds of formula (1).
La présente invention concerne des composés représentés par la formule générale (1), ainsi que certains de leurs sels et solvates. Dans cette formule, R<1>, R<2>, R<3>, R<4>, R<5>, R<6>, R<7>, R<8>, R<9>, et Z sont tels que définis dans les revendications. L'invention concerne également, d'une part des compositions pharmaceutiques contenant des composés de la formule générale (1), et d'autre part des procédés permettant de bloquer la croissance cellulaire anormale, y-compris cancéreuse, chez un mammifère, et ce, par administration au mammifère considéré de composés de la formule générale (1). L'invention concerne enfin des intermédiaires et des procédés permettant la synthèse des composés de la formule générale (1).
Pfizer Products Inc.
Smart & Biggar
LandOfFree
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