Libraries of polyhydroxamates and their analogs

Details Libraries of polyhydroxamates and their analogs Libraries of polyhydroxamates and their analogs

C - Chemistry, Metallurgy

07

C

C07C 239/08 (2006.01) A61K 31/16 (2006.01) A61K 31/195 (2006.01) A61K 31/4402 (2006.01) A61K 31/662 (2006.01) C07C 233/00 (2006.01) C07C 239/00 (2006.01) C07C 241/00 (2006.01) C07C 255/00 (2006.01) C07C 259/04 (2006.01) C07C 259/06 (2006.01) C07C 327/40 (2006.01) C07C 331/00 (2006.01) C07C 381/00 (2006.01) C07D 213/56 (2006.01) C07F 9/38 (2006.01) G01N 33/53 (2006.01) G01N 33/543 (2006.01) G01N 33/566 (2006.01) G01N 33/567 (2006.01) C07B 61/00 (2006.01)

Patent

CA 2337756

A method of synthesizing desired polyhydroxamates and polyhydroxamate analogs is provided. The method comprises linking a first component of the desired polyhydroxamate or polyhydroxamate analog to a support matrix under conditions effective to form a first matrix-bound intermediate of said desired polyhydroxamate or analog, extending said first matrix-bound intermediate using reagents and reaction conditions effective to form one or more additional matrix-bound intermediates of said desired polyhydroxamate or analog, thereby forming a matrix-bound precursor of the desired polyhydroxamate or polyhydroxamate analog. Protective groups used during synthesis of the precursor are removed and the matrix-bound precursor is cleared from the support matrix, thereby synthesizing the desired polyhydroxamate or polyhydroxamate analog. Methods of making, screening and selecting libraries of candidate polyhydroxamates, the libraries and polyhydroxamates, polyhydroxamate analogs, their intermediates, and methods for using such compounds and their compositions are also disclosed.

L'invention concerne un procédé de synthèse de polyhydroxamates voulus et d'analogues de polyhydroxamates. Le procédé consiste à lier un premier composant du polyhydroxamate voulu ou d'un analogue de polyhydroxamate à une matrice de support dans des conditions effectives pour former un premier intermédiaire lié à la matrice de ce polyhydroxamate voulu ou de son analogue; à étendre ce premier intermédiaire lié à la matrice au moyen de réactifs dans des conditions de réaction effectives pour former un ou plusieurs intermédiaires supplémentaires liés à la matrice de ce polyhydroxamate voulu ou de son analogue, ce qui permet de former un précurseur lié à la matrice du polyhydroxamate voulu ou de l'analogue de polyhydroxamate. On retire les groupes protecteurs utilisés lors de la synthèse du précurseur et on enlève de la matrice de support le précurseur lié à la matrice, ce qui permet d'effectuer une synthèse du polyhydroxamate voulu ou de l'analogue de polyhydroxamate. L'invention concerne également des procédés de production, de criblage et de sélection de banques de polyhydroxamates candidats, des banques et des polyhydroxamates d'analogues de polyhydroxamates, de leurs intermédiaires, ainsi que des procédés d'utilisation de ces composés et de leurs compositions.

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